Von Willebrand Factor (3E2D10), CF405S conjugate, 0.1mg/mL

About this product

Von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi's sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC040633-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Coagulation Factor VIII, Factor VIII Related Antigen, F8VWF, von Willebrand Antigen 2, von Willebrand Disease (vWD)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

VWF

Gene ID

7450

NCBI Gene ID

440848

UniProt

P04275

Swiss Prot

P04275

Host

Mouse

Species Reactivity

Human

Reactivity

Von Willebrand Factor|vWF

Immunogen

Recombinant human vWF fragment spanning aa 845-949

Target Antigen

von Willebrand Factor | vWF

Clonality

Monoclonal

Clone

3E2D10

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, intracellular (published) |IF (verified) |IHC, FFPE (verified) |WB (published)

Field of Research

Hematology

Positive Control

HUVEC cells or Tonsil

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

250 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. J Biol Chem (2008) 283(15): 9531-9542. (western) Transplant Direct. 2017 May; 3(5): e153. (flow, intracellular)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF405S