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Product details

Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL

Catalog number BNC742377-100

Price for BNC742377-100

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Size / count 1x 100 µL

About this product

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNC742377-100
Size / count
1x 100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase; GRIPGHS; Macrophage activation-associated marker protein P71/73; PES-2; PGG/HS; PGHS-2; Prostaglandin endoperoxide synthase 2; Prostaglandin endoperoxide synthase 2 (PTGS2) ; TIS10
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
PTGS2
Gene ID
5743
NCBI Gene ID
196384
UniProt
P35354
Swiss Prot
P35354
Host
Mouse
Species Reactivity
Human
Reactivity
Cycloxygenase-2
Immunogen
Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
Target Antigen
Cycloxygenase-2
Clonality
Monoclonal
Clone
COX2/1941
Type
Primary
Source
Animal
Origin
Animal
Positive Control
Colon or Lung Carcinoma. HepG2 cells.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% rBSA, 0.05% azide
Molecular Weight
70-72 kDa
References & Citations
Wang, D, et al. Oncogene. 2010 Feb 11; 29(6): 781-78
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2b, kappa
Species
Mus musculus (mouse), Bos taurus (bovine)
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF740

Frequently Asked Questions

What is the catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL?

The catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL is BNC742377-100.

What sizes are available for Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL in stock?

Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL?

The safety data sheet for Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Cycloxygenase-2 (COX-2) (COX2/1941), CF740 conjugate, 0.1mg/mL used for?

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that

Can I return this product if I ordered the wrong one?

As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

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