DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL — image 1 of 3

Product details

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL

Catalog number BNC041485-500

Price for BNC041485-500

Size / count 1x 500 µL

About this product

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC041485-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TMEM16A
Gene ID: 55107
NCBI Gene ID: 503074
UniProt: Q5XXA6
Swiss Prot: Q5XXA6
Host: Mouse
Species Reactivity: Human
Reactivity: DOG-1|TMEM16A
Immunogen: Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
Target Antigen: DOG-1 | TMEM16A
Clonality: Monoclonal
Clone: DG1/1485
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer
Positive Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ~114 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL?

The catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL is BNC041485-500.

What sizes are available for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL in stock?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL?

The safety data sheet for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0297061270361e100506/msds/bnc041485-500.pdf.

What is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF405S conjugate, 0.1mg/mL used for?

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.