SensiStain™ Anti-BSEP Antibody

About this product

SensiStain Anti-BSEP Antibody is validated for the detection of bile salt export pump (BSEP) which has a role in the transport of bile acid, taurocholate, and other cholate conjugates across the hepatocyte canalicular membrane. BSEP has been associated with disorders such as, progressive familial intrahepatic cholestasis type 2 (PFIC2) and benign recurrent intrahepatic cholestasis type 2 (BRIC2). <br />Bile Salt Export Pump (BSEP) is a membrane associated protein encoded by the ABCB11 gene &ndash; a member of the superfamily ATP-binding cassette (ABC) transporters. BSEP functions as a canalicular bile salt export pump and facilitates the transport of bile acid and other cholate conjugates across the canalicular membrane into the canaliculus. BSEP is associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) and benign recurrent intrahepatic cholestasis type 2 (BRIC2). PFIC2 is an inherited disorder linked to mutations in the BSEP gene that increase the risk of developing cholestatic liver disease and hepatocellular carcinoma early in life.

Specifications

Catalog number

HY000021

Size / count

0.1 mL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Reactivity

Human

Immunogen

Recombinant Protein

Clonality

Monoclonal

Clone

IHC518

Type

Antbodies-IHC

Applications

ELISA, IHC

Purity

Purified

Buffer

Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide

Shipping Conditions

Ice Pack

Storage Conditions

This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Fragment

IgG1

Specificity

BSEP

Applications Notes

1:50-1:200