Munc18-1 Recombinant Rabbit Monoclonal Antibody [JE38-54]

About this product

Syntaxin-binding protein 1 (also known as Munc18-1) is a protein that in humans is encoded by the STXBP1 gene. This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with neurological disorders including epilepsy, intellectual disability, and movement disorders. The encoded protein may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. It is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. It can interact with syntaxins 1, 2, and 3 but not syntaxin 4 and may play a role in determining the specificity of intracellular fusion reactions. This protein functions in a late stage of the intracellular membrane fusion process of exocytosis. Dissociation of this protein from syntaxin determines the kinetics of postfusion events. This protein is essential for presynpatic vesicle release and is rapidly phosphorylated by protein kinase C upon neuronal depolarization. The protein participates in the secretory pathway between the Golgi apparatus and cell membrane.

Specifications

Catalog number

HA722250

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

FLJ37475 antibody Munc 18 1 antibody Munc 18a antibody MUNC18 1 antibody N-Sec1 antibody Neuronal SEC1 antibody NSec1 antibody p67 antibody Protein unc-18 homolog 1 antibody Protein unc-18 homolog A antibody Rb sec1 antibody RBSEC1 antibody STXB1_HUMAN antibody STXBP1 antibody Syntaxin binding protein 1 antibody Syntaxin-binding protein 1 antibody Unc 18 homolog antibody Unc 18A antibody Unc-18A antibody Unc18 1 antibody UNC18 antibody Unc18-1 antibody

Abbreviation

STXBP1, UNC18A

Swiss Prot

P61764 Human, O08599 Mouse, P61765 Rat

Cellular Locus

Cytoplasm, cytosol, Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human Munc18-1 aa 401-500 / 594.

Isotype

IgG

Clone

JE38-54

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Tissue

Positive Control

SH-SY5Y cell lysate, SiHa cell lysate, HeLa cell lysate, Jurkat cell lysate, K-562 cell lysate, NIH/3T3 cell lysate, MEF cell lysate, C6 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, human testis tissue, human brain tissue, mouse brain tissue, rat brain tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IHC-P: 1:200-1:1,000 ;IF-Tissue: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes