Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL

Catalog number BNC471846-100

Price for BNC471846-100

Size / count 1x 100 µL

About this product

Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC471846-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DGSX; Glypican proteoglycan 3; GPC3; GTR2-2; Heparan sulphate proteoglycan; Intestinal protein OCI-5; MXR7; OCI-5; SDYS; Secreted glypican-3; SGBS1
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: GPC3
Gene ID: 2719
NCBI Gene ID: 644108
UniProt: P51654
Swiss Prot: P51654
Host: Mouse
Species Reactivity: Human, Rat
Reactivity: Glypican-3
Immunogen: Recombinant full-length human GPC3 protein
Target Antigen: Glypican-3
Clonality: Recombinant Monoclonal
Clone: RGPC3/863
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow (verified) |IF (verified) |IHC, FFPE (verified)
Field of Research: Cancer
Positive Control: 293T cells or Hepatocellular carcinoma
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 67 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL?

The catalog number for Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL is BNC471846-100.

What sizes are available for Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL?

Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL in stock?

Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL?

Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL?

The safety data sheet for Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02aa061270361e1076e0/msds/bnc471846-100.pdf.

What is Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) (rGPC3/863), CF647 conjugate, 0.1mg/mL used for?

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.