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![Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH04-52] — image 1 of 1](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea81ed2/imageurl/ha722151.webp)
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Product details
Catalog number HA722151
Price for HA722151
Size / count 100 µL
LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cells. LRP2 is an approximately 600kDa (4665 amino acids) transmembrane glycoprotein with structural similarities to the low density lipoprotein receptor (LDLR). LRP2 has a NPXY motif that is the binding site for Dab2 to initiate clathrin-mediated endocytosis. LRP2 forms a homodimer that changes conformation in response to pH. At pH 7.5 (extracellular pH), LRP2 is considered active, with the leucine loops in an open conformation to allow ligands to bind.[11] At acidic endosomal pHs, the leucine loops collapse to prevent ligands binding.
The catalog number for Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH04-52] is HA722151.
Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH04-52] is available in the following size(s): 100 µL.
Lrp2 / Megalin Recombinant Rabbit Monoclonal Antibody [PSH04-52] is currently made to order / not held in immediate stock. Contact us for lead time.
LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cells. LRP2 is an approximate
Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.
Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.
If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.
