Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64]

Catalog number HA601285

Price for HA601285

Size / count 100 µL

About this product

The protein product of this gene, best known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains, and thus belongs to the receptor type PTP family. CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signalling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling. Many alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. Antibodies against the different isoforms of CD45 are used in routine immunohistochemistry to differentiate between immune cell types, as well as to differentiate between histological sections from lymphomas and carcinomas.

Specifications

Catalog number: HA601285
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: B220 antibody CD 45 antibody CD45 antibody CD45 antigen antibody CD45R antibody GP180 antibody L-CA antibody LCA antibody Leukocyte common antigen antibody loc antibody Ly-5 antibody LY5 antibody Ly5, homolog of antibody Lyt-4 antibody OTTHUMP00000033813 antibody OTTHUMP00000033816 antibody OTTHUMP00000033817 antibody OTTHUMP00000038574 antibody Protein tyrosine phosphatase receptor type c polypeptide antibody Protein tyrosine phosphatase, receptor type C antibody protein tyrosine phosphatase, receptor type, C antibody Protein tyrosine phosphatase, receptor type, c polypeptide antibody Ptprc antibody PTPRC_HUMAN antibody Receptor-type tyrosine-protein phosphatase C antibody T200 antibody T200 glycoprotein antibody T200 leukocyte common antigen antibody
Abbreviation: PTPRC, CD45
Swiss Prot: P08575 Human
Cellular Locus: Cell membrane, Membrane raft.
Host: Mouse
Species Reactivity: Human
Immunogen: Synthetic peptide.
Isotype: IgG1
Clone: PSH03-64
Conjugation: Non-conjugated
Type: Recombinant Mouse monoclonal Antibody
Applications: IF-Cell, FC
Positive Control: Raji, human PBMC.
Concentration: 1 mg/mL
Dilution: IF-Cell: 1:100 ;FC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 147 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64]?

The catalog number for Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64] is HA601285.

What sizes are available for Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64]?

Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64] is available in the following size(s): 100 µL.

Is Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64] in stock?

Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Human CD45 Recombinant Mouse Monoclonal Antibody [PSH03-64] used for?

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

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Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.