DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL — image 1 of 3

Product details

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL

Catalog number BNC941484-100

Price for BNC941484-100

Size / count 1x 100 µL

About this product

Expression of DOG-1 protein is elevated in gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC941484-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TMEM16A
Gene ID: 55107
NCBI Gene ID: 503074
UniProt: Q5XXA6
Swiss Prot: Q5XXA6
Host: Mouse
Species Reactivity: Human
Reactivity: DOG-1|TMEM16A
Immunogen: Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
Target Antigen: DOG-1 | TMEM16A
Clonality: Monoclonal
Clone: DG1/1484
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer
Positive Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ~114 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF594

Frequently Asked Questions

What is the catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL?

The catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL is BNC941484-100.

What sizes are available for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL in stock?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL?

The safety data sheet for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1484), CF594 conjugate, 0.1mg/mL used for?

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.