HLA-Pan (MHC II) (HLA-Pan/2967R), Biotin conjugate, 0.1mg/mL

About this product

This antibody reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa) . They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six alpha and ten beta chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNCB2967-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

HLA-DPB1; HLA-DQA1; HLA-DQB1; HLA-DRA; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

HLA-DP; HLA-DQ; HLA-DR

Gene ID

3115 (HLA-DP); 3117 (HLA-DQ); 3122 (HLA-DR)

NCBI Gene ID

347270 (HLA-DP); 550475 (HLA-DQ); 520048 (HLA-DR)

UniProt

P04440 (HLA-DP); P01908; P01909; P01920 (HLA-DQ); P01903 (HLA-DR)

Swiss Prot

P04440 (HLA-DP) ; P01908; P01909; P01920 (HLA-DQ) ; P01903 (HLA-DR)

Host

Rabbit

Species Reactivity

Human

Reactivity

HLA-DP/-DQ/-DR

Immunogen

Non-T, non-B human acute lymphoblastic leukemia REH6 cell line

Target Antigen

HLA-DP/-DQ/-DR

Clonality

Recombinant Monoclonal

Clone

HLA-Pan/2967R

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |IF (verified) |IHC, FFPE (verified) |WB (verified)

Field of Research

Cancer, Immunology, MHC antigens

Positive Control

Raji cells. Tonsil or lymph node

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

33-35 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG

Species

Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

Biotin