ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL — image 1 of 2

Product details

ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2296-500

Price for BNCB2296-500

Size / count 1x 500 µL

About this product

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH) ; does not react with Synacthen (aa1-24 of ACTH) . POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs) .It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2296-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Pro-opiomelanocortin (POMC) ; Adrenocorticotropin; Adrenocorticotropic hormone; Melanocyte Stimulating Hormone (MSH) ; Melanotropin; beta-Endorphin; Lipotropin; Met-Enkephalin; POC
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: POMC
Gene ID: 5443
NCBI Gene ID: 1897
UniProt: P01189
Swiss Prot: P01189
Host: Mouse
Species Reactivity: Multiple species, Human, Mouse, Rat
Reactivity: ACTH
Immunogen: Synthetic peptide corresponding to (aa 162-176) of human ACTH (NGAEDESAEAFPLEF)
Target Antigen: ACTH
Clonality: Recombinant Monoclonal
Clone: RCLIP/1407
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer, Endocrinology
Positive Control: Normal pituitary gland or pituitary tumor
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ACTH is ~5 kDa, and the POMC precursor is ~30 kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL?

The catalog number for ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL is BNCB2296-500.

What sizes are available for ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL?

ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL in stock?

ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL?

ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL?

The safety data sheet for ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) (rCLIP/1407), Biotin conjugate, 0.1mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.