DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL — image 1 of 2

Product details

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2564-500

Price for BNCB2564-500

Size / count 1x 500 µL

About this product

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST s, including all c-kit negative GIST s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST s is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2564-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TMEM16A
Gene ID: 55107
NCBI Gene ID: 503074
UniProt: Q5XXA6
Swiss Prot: Q5XXA6
Host: Rabbit
Species Reactivity: Human
Reactivity: DOG-1|TMEM16A
Immunogen: Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
Target Antigen: DOG-1 | TMEM16A
Clonality: Recombinant Monoclonal
Clone: DG1/2564R
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cancer
Positive Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ~114 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Species: Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL?

The catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL is BNCB2564-500.

What sizes are available for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL in stock?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL?

The safety data sheet for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0299061270361e100f6c/msds/bncb2564-500.pdf.

What is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/2564R), Biotin conjugate, 0.1mg/mL used for?

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.