SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL — image 1 of 2

Product details

SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2311-500

Price for BNCB2311-500

Size / count 1x 500 µL

About this product

SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas.In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2311-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E (WS2E) ; WS4; Waardenburg syndrome type 4C (WS4C)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: SOX10
Gene ID: 6663
NCBI Gene ID: 376984
UniProt: P56693
Swiss Prot: P56693
Host: Rabbit
Species Reactivity: Human, Mouse
Reactivity: SOX10
Immunogen: Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary)
Target Antigen: SOX10
Clonality: Recombinant Monoclonal
Clone: SOX10/2311R
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Field of Research: Cancer, Developmental biology, Transcription factors
Positive Control: HepG2 cells. Melanomas, breast carcinomas, gliomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 49-58 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Species: Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL?

The catalog number for SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL is BNCB2311-500.

What sizes are available for SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL?

SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL in stock?

SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL?

SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL?

The safety data sheet for SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is SOX10 (Melanoma Marker) (SOX10/2311R), Biotin conjugate, 0.1mg/mL used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.