VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL

Catalog number BNC743006-100

Price for BNC743006-100

Size / count 1x 100 µL

About this product

VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment) . It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC743006-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: B7H5; DD1alpha; GI24; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; Stress-induced secreted protein 1 (SISP1) ; V domain Ig suppressor of T cell activation; V Set Immuno-regulatory Receptor
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: VSIR
Gene ID: 64115
NCBI Gene ID: 47382
UniProt: Q9H7M9
Swiss Prot: Q9H7M9
Host: Mouse
Species Reactivity: Human
Reactivity: GI24|VISTA
Immunogen: Recombinant full-length human VISTA protein
Target Antigen: GI24 | VISTA
Clonality: Monoclonal
Clone: VISTA/3006
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Human spleen or placenta tissue (IHC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 34 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL?

The catalog number for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL is BNC743006-100.

What sizes are available for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL?

VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL in stock?

VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL?

VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL?

The safety data sheet for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0297061270361e100561/msds/bnc743006-100.pdf.

What is VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/3006), CF740 conjugate, 0.1mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.