HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL

Catalog number BNC743073-100

Price for BNC743073-100

Size / count 1x 100 µL

About this product

The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first through the binding of p53 and the second through the binding of the viral genome. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC743073-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: HPV16 regulatory protein E2; Human papilloma virus 16 E2; Human papilloma virus 16 regulatory protein E2; Human papillomavirus type 16 E2; Human papillomavirus type 16 regulatory protein E2; Regulatory protein E2
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: Not Applicable
UniProt: Not Applicable
Swiss Prot: Not Applicable
Host: Mouse
Species Reactivity: HPV-16
Reactivity: HPV16 E2
Immunogen: Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2
Target Antigen: HPV16 E2
Clonality: Monoclonal
Clone: TVG 261
Type: Primary
Source: Animal
Origin: Animal
Applications: IF (published) |WB (published)
Positive Control: HPV-16 infected cells. Cervical tissue.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 43 kDa
References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. J Virol(2003) 77(3): 2021-2028. (WB) J Virol (2017) 91(5): e02305-16. (IF) Virology (2018) 521: 62-68. (WB)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL?

The catalog number for HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL is BNC743073-100.

What sizes are available for HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL?

HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL in stock?

HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL?

HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL?

The safety data sheet for HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is HPV16 E2 (Human Papilloma Virus 16) (TVG 261), CF740 conjugate, 0.1mg/mL used for?

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.