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Product details

MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL

Catalog number BNC742622-100

Price for BNC742622-100

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Size / count 1x 100 µL

About this product

Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) . Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNC742622-100
Size / count
1x 100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
BAT26; COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC1; LCFS2; MSH2; MutS homolog 2; MutS homolog 2 colon cancer nonpolyposis type 1; MutS protein homolog 2
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
MSH2
Gene ID
4436
NCBI Gene ID
597656
UniProt
IDP43246
Swiss Prot
IDP43246
Host
Mouse
Species Reactivity
Human
Reactivity
MSH2
Immunogen
Recombinant fragment (around aa 327-427) of human MSH2 protein (exact sequence is proprietary)
Target Antigen
MSH2
Clonality
Monoclonal
Clone
MSH2/2622
Type
Primary
Source
Animal
Origin
Animal
Applications
Flow, intracellular (verified) |IF (verified) |IHC, FFPE (verified) |WB (verified)
Positive Control
A549 or HepG2 cells. Colon, Thyroid, Testis or Lymph Node.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% rBSA, 0.05% azide
Molecular Weight
100 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), Bos taurus (bovine)
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF740

Frequently Asked Questions

What is the catalog number for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL?

The catalog number for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL is BNC742622-100.

What sizes are available for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL?

MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL in stock?

MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL?

MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL?

The safety data sheet for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF740 conjugate, 0.1mg/mL used for?

Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) . Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated w

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

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