NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture)

Catalog number HA601223

Price for HA601223

Size / count 100 µg

About this product

Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division. Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles. Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner. In metaphase, part of a ternary complex composed of GPSM2 and G (i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle. During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI (4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation. Also required for proper orientation of the mitotic spindle during asymmetric cell divisions. Plays a role in mitotic MT aster assembly. Positively regulates TNKS protein localization to spindle poles in mitosis.

Specifications

Catalog number: HA601223
Size / count: 100 µg
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Product Name Alternative: Centrophilin stabilizes mitotic spindle in mitotic cells antibody NMP 22 antibody Nuclear matrix protein 22 antibody Nuclear mitotic apparatus protein 1 antibody Nuclear mitotic apparatus protein antibody NUMA 1 antibody NUMA antibody NuMA protein antibody NUMA1 antibody NUMA1_HUMAN antibody SP H antigen antibody SP-H antigen antibody Structural nuclear protein antibody
Abbreviation: Nuclear mitotic apparatus protein 1 Nuclear matrix protein-22 Nuclear mitotic apparatus protein SP-H antigen NUMA1 NMP22 NUMA
Swiss Prot: Q14980 Human
Cellular Locus: Nucleus, Cytoskeleton, Plasma membrane.
Host: Mouse
Species Reactivity: Human
Immunogen: Recombinant protein within Human NuMA aa 1-200 / 2,115.
Isotype: IgG1
Clone: PSH03-07
Conjugation: Non-conjugated
Type: Mouse monoclonal Antibody
Applications: ELISA (Cap)
Concentration: 1 mg/mL
Dilution: ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Mouse monoclonal [PSH03-08] to Human NuMA (Detector) (HA601224). The reference range value is 51-12500 pg/ml.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: PBS (pH7.4).
Molecular Weight: Predicted band size: 238 kDa kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody: No

Frequently Asked Questions

What is the catalog number for NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture)?

The catalog number for NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture) is HA601223.

What sizes are available for NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture)?

NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture) is available in the following size(s): 100 µg.

Is NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture) in stock?

NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture) is currently made to order / not held in immediate stock. Contact us for lead time.

What is NuMA Mouse Monoclonal Antibody [PSH03-07] - BSA and Azide free (Capture) used for?

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.