Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL

Catalog number BNC743232-500

Price for BNC743232-500

Size / count 1x 500 µL

About this product

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC743232-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase; GRIPGHS; Macrophage activation-associated marker protein P71/73; PES-2; PGG/HS; PGHS-2; Prostaglandin endoperoxide synthase 2; Prostaglandin endoperoxide synthase 2 (PTGS2) ; TIS10
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: PTGS2
Gene ID: 5743
NCBI Gene ID: 196384
UniProt: P35354
Swiss Prot: P35354
Host: Rabbit
Species Reactivity: Human
Reactivity: Cycloxygenase-2
Immunogen: Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
Target Antigen: Cycloxygenase-2
Clonality: Recombinant Monoclonal
Clone: COX2/3232R
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Human colon or lung carcinoma tissue (IHC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% rBSA, 0.05% azide
Molecular Weight: 70-72 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF740

Frequently Asked Questions

What is the catalog number for Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL?

The catalog number for Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL is BNC743232-500.

What sizes are available for Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL in stock?

Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL?

Estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL?

The safety data sheet for Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Cycloxygenase-2 (COX-2) (COX2/3232R), CF740 conjugate, 0.1mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.