Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL

Catalog number BNC041884-500

Price for BNC041884-500

Size / count 1x 500 µL

About this product

This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC041884-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DTMP synthase; TMS; TS; TSase; TYMS protein; Tyms thymidylate synthetase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMS
Gene ID: 7298
NCBI Gene ID: 369762
UniProt: P04818
Swiss Prot: P04818
Host: Mouse
Species Reactivity: Human
Reactivity: Thymidylate Synthase
Immunogen: Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
Target Antigen: Thymidylate Synthase
Clonality: Monoclonal
Clone: TYMS/1884
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified) |IHC, FFPE (verified)
Field of Research: Cancer, Metabolism
Positive Control: MOLT4; Ramos, 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2c, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL?

The catalog number for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL is BNC041884-500.

What sizes are available for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL in stock?

Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL?

The safety data sheet for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF405S conjugate, 0.1mg/mL used for?

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.