Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL

Catalog number BNC881945-500

Price for BNC881945-500

Size / count 1x 500 µL

About this product

Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC881945-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ATOD2; Epidermal Filaggrin; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: FLG
Gene ID: 2312
NCBI Gene ID: 654510
UniProt: P20930
Swiss Prot: P20930
Host: Mouse
Species Reactivity: Human
Reactivity: Filaggrin
Immunogen: Recombinant human Filaggrin protein fragment (around aa 998-1104) (exact sequence is proprietary)
Target Antigen: Filaggrin
Clonality: Monoclonal
Clone: FLG/1945
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cell adhesion
Positive Control: U-251-MG cells. Skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 26-45 kDa (Processed) ; 350 kDa (Profilaggrin)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL?

The catalog number for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL is BNC881945-500.

What sizes are available for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL in stock?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL?

The safety data sheet for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Filaggrin (Keratinocyte Differentiation Marker) (FLG/1945), CF488A conjugate, 0.1mg/mL used for?

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.