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Product details
Catalog number BNC882563-500
Price for BNC882563-500
Size / count 1x 500 µL
This MAb recognizes a protein of 67 kDa, which is identified as glutamic acid decarboxylase 1 (GDA1) . There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (ÃŽ3-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2563), CF488A conjugate, 0.1mg/mL is BNC882563-500.
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2563), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2563), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2563), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2563), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2563), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
This MAb recognizes a protein of 67 kDa, which is identified as glutamic acid decarboxylase 1 (GDA1) . There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarbo
The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.
As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.
Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
