- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
Product details
Catalog number BNC882337-100
Price for BNC882337-100
Size / count 1x 100 µL
This antibody recognizes a protein of 35 kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP) . It exists as two isoforms (5a and 5b) . This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L () -tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Supporting information for this product.
Add the product and required quantity to your cart, then submit the quotation request from the checkout page. Include your contact and delivery details so the Afraxis team can respond.
Check the product description, specifications and catalogue number on this page. If the product has multiple variants, select the required catalogue number and size before adding it to your cart.
Available product documents are listed in the Product documents section on this page. If a document you need is not listed, contact Afraxis and include the product name and catalogue number.
The product page shows the available variant and any displayed price information. For a quotation or confirmation for your order, add the product to your cart and submit a request.
Delivery timing depends on the product, supplier and destination. Request a quotation with your delivery details to confirm the expected timing for your order.
Review any product-specific handling details shown on this page. If you are unsure about storage or shipping requirements, contact Afraxis with the product name and catalogue number.
Afraxis products are supplied for laboratory and research use. Review the product documentation and intended-use information before use.
Use the contact form or contact details on the Afraxis website. Include the product name and catalogue number so the team can assist with your enquiry.
