SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL — image 1 of 2

Product details

SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL

Catalog number BNC882312-100

Price for BNC882312-100

Size / count 1x 100 µL

About this product

SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC882312-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E (WS2E) ; WS4; Waardenburg syndrome type 4C (WS4C)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: SOX10
Gene ID: 6663
NCBI Gene ID: 376984
UniProt: P56693
Swiss Prot: P56693
Host: Mouse
Species Reactivity: Human, Mouse
Reactivity: SOX10
Immunogen: Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary)
Target Antigen: SOX10
Clonality: Recombinant Monoclonal
Clone: RSOX10/1074
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Field of Research: Cancer, Developmental biology, Transcription factors
Positive Control: HepG2 cells. Melanomas, breast carcinomas, gliomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 49-58 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL?

The catalog number for SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL is BNC882312-100.

What sizes are available for SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL?

SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL in stock?

SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL?

SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL?

The safety data sheet for SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is SOX10 (Melanoma Marker) (rSOX10/1074), CF488A conjugate, 0.1mg/mL used for?

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.