Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL — image 1 of 2

Product details

Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL

Catalog number BNC882890-100

Price for BNC882890-100

Size / count 1x 100 µL

About this product

This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic) . Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5€TM-deoxy-5-fluorouridine to 5-FU) . High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC882890-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ECGF; ECGF1; Gliostatin; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; Tymp
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMP
Gene ID: 1890
NCBI Gene ID: 180903
UniProt: P19971
Swiss Prot: P19971
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Reactivity: PD-ECGF|Thymidine Phosphorylase
Immunogen: Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
Target Antigen: PD-ECGF | Thymidine Phosphorylase
Clonality: Recombinant Monoclonal
Clone: TYMP/2890R
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Angiogenesis, Metabolism
Positive Control: HUVEC cells. Breast, Bladder, Lung or Kaposi tumors
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 55 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Species: Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL?

The catalog number for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL is BNC882890-100.

What sizes are available for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL?

Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL in stock?

Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL?

Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL?

The safety data sheet for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF488A conjugate, 0.1mg/mL used for?

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.