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Product details
Catalog number BNC682208-500
Price for BNC682208-500
Size / count 1x 500 µL
This antibody recognizes a protein of 120-80 kDa, identified as E-cadherin. Cadherins comprise a family of calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/2208R), CF568 conjugate, 0.1mg/mL is BNC682208-500.
E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/2208R), CF568 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/2208R), CF568 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/2208R), CF568 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/2208R), CF568 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for E-Cadherin (CDH1) / CD324 (Intercellular Junction Marker) (CDH1/2208R), CF568 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0298061270361e100d92/msds/bnc682208-500.pdf.
This antibody recognizes a protein of 120-80 kDa, identified as E-cadherin. Cadherins comprise a family of calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin
Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.
A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.
Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.
