Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL

Catalog number BNC681982-500

Price for BNC681982-500

Size / count 1x 500 µL

About this product

Bcl-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. It forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Bcl-6 allows GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. Antibodies to Bcl-6 are helpful in a number of diagnostic settings, for example in the differential diagnosis of small B-cell lymphoma, and in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) .Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC681982-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Bcl-6; B-Cell Lymphoma 6 Protein; B-cell lymphoma 5 protein; Zinc Finger Protein 51; zinc finger transcription factor BCL6S; BCL6 Transcription Repressor
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: BCL6
Gene ID: 604
NCBI Gene ID: 478588
UniProt: P41182
Swiss Prot: P41182
Host: Mouse
Species Reactivity: Human
Reactivity: Bcl-6
Immunogen: Recombinant human bcl-6 protein fragment (around aa256-389) (Exact sequence is proprietary)
Target Antigen: Bcl-6
Clonality: Monoclonal
Clone: BCL6/1982
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Apoptosis, Cancer, Immunology, Transcription factor
Positive Control: Raji or Ramos cells. Tonsil or Hodgkin's lymphoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 95 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF568

Frequently Asked Questions

What is the catalog number for Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL?

The catalog number for Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL is BNC681982-500.

What sizes are available for Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL?

Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL in stock?

Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL?

Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL?

Estimated delivery time for Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL?

The safety data sheet for Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029c061270361e1022f0/msds/bnc681982-500.pdf.

What is Bcl-6 (Follicular Lymphoma Marker) (BCL6/1982), CF568 conjugate, 0.1mg/mL used for?

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.