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Product details
Catalog number BNC682468-100
Price for BNC682468-100
Size / count 1x 100 µL
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8 T-cells, natural killer cells and some CD4 T-cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF568 conjugate, 0.1mg/mL is BNC682468-100.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF568 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF568 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF568 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF568 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF568 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b4061270361e10abf7/msds/bnc682468-100.pdf.
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tub
Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.
Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.
A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.
