Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL

Catalog number BNC681884-100

Price for BNC681884-100

Size / count 1x 100 µL

About this product

This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45) . It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC681884-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DTMP synthase; TMS; TS; TSase; TYMS protein; Tyms thymidylate synthetase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYMS
Gene ID: 7298
NCBI Gene ID: 369762
UniProt: P04818
Swiss Prot: P04818
Host: Mouse
Species Reactivity: Human
Reactivity: Thymidylate Synthase
Immunogen: Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
Target Antigen: Thymidylate Synthase
Clonality: Monoclonal
Clone: TYMS/1884
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified) |IHC, FFPE (verified)
Field of Research: Cancer, Metabolism
Positive Control: MOLT4; Ramos, 5-FU-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1); 5-FU-resistant breast cancer cell lines, MCF-Ad5 and MCF-Ad10. Testicular carcinomas.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2c, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF568

Frequently Asked Questions

What is the catalog number for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL?

The catalog number for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL is BNC681884-100.

What sizes are available for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL in stock?

Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL?

Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL?

Estimated delivery time for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL?

The safety data sheet for Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02ad061270361e108963/msds/bnc681884-100.pdf.

What is Thymidylate Synthase (5-FU Resistance Marker) (TYMS/1884), CF568 conjugate, 0.1mg/mL used for?

What applications has this product been validated for?

Validated applications such as WB, ELISA, IHC, ICC, or FC are listed on the product datasheet. If you need application-specific validation data before ordering, contact our technical support team with the catalogue number.

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.