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Product details
Catalog number BNC942890-500
Price for BNC942890-500
Size / count 1x 500 µL
This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic) . Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5€TM-deoxy-5-fluorouridine to 5-FU) . High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL is BNC942890-500.
Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) (TYMP/2890R), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
This antibody recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cle
Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.
Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.
We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.
