Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL

Catalog number BNC401957-500

Price for BNC401957-500

Size / count 1x 500 µL

About this product

Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC401957-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ATOD2; Epidermal Filaggrin; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: FLG
Gene ID: 2312
NCBI Gene ID: 654510
UniProt: P20930
Swiss Prot: P20930
Host: Rabbit
Species Reactivity: Human
Reactivity: Filaggrin
Immunogen: Recombinant human Filaggrin protein fragment (around aa 198-288) (exact sequence is proprietary)
Target Antigen: Filaggrin
Clonality: Recombinant Monoclonal
Clone: FLG/1957R
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Cell adhesion
Positive Control: U-251-MG cells. Skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 26-45 kDa (Processed) ; 350 kDa (Profilaggrin)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Species: Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF640R

Frequently Asked Questions

What is the catalog number for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL?

The catalog number for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL is BNC401957-500.

What sizes are available for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL in stock?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL?

The safety data sheet for Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Filaggrin (Keratinocyte Differentiation Marker) (FLG/1957R), CF640R conjugate, 0.1mg/mL used for?

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.