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Product details
Catalog number BNC402391-100
Price for BNC402391-100
Size / count 1x 100 µL
This MAb recognizes a protein of 67 kDa, which is identified as glutamic acid decarboxylase 1 (GDA1) . There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD65 localizes to synaptic vesicle membranes in nerve terminals, while GAD67 is distributed throughout the cell. GAD67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD65 will transiently activate to assist in GABA production. The loss of GAD65 is detrimental and can impair GABA neurotransmission, however the loss of GAD67 is lethal. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2391), CF640R conjugate, 0.1mg/mL is BNC402391-100.
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2391), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2391), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2391), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2391), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for GAD1 / GAD67 (GABAergic Neuronal Marker) (GAD1/2391), CF640R conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
This MAb recognizes a protein of 67 kDa, which is identified as glutamic acid decarboxylase 1 (GDA1) . There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD65 (also known as GAD2) and GAD67 (also known as GAD1. GAD65 and GAD67 are members of the group II decarbo
A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.
Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.
Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.
