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Product details

Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL

Catalog number BNC472174-100

Price for BNC472174-100

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Size / count 1x 100 µL

About this product

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18) . CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19) . Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNC472174-100
Size / count
1x 100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
CARD2; CK8; CYK8; CYKER; Cytokeratin Endo A; DreK8; EndoA; K2C8; K8; Keratin 8; Krt 2.8; KRT8; Type-II Keratin Kb8
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
KRT8
Gene ID
3856
NCBI Gene ID
533782; 708445
UniProt
P05787
Swiss Prot
P05787
Host
Rabbit
Species Reactivity
Cow, Human, Pig, Rabbit, Sheep
Reactivity
Cytokeratin 8
Immunogen
Recombinant full-length human KRT8 protein
Target Antigen
Cytokeratin 8
Clonality
Recombinant Monoclonal
Clone
KRT8/2174R
Type
Primary
Source
Animal
Origin
Animal
Applications
IHC, FFPE (verified) |WB (verified)
Field of Research
Cancer, Cytoskeleton
Positive Control
MCF-7 or A431 cells. Skin, Colon, lung or breast carcinoma
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
52.5 kDa
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG
Species
Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF647

Frequently Asked Questions

What is the catalog number for Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL?

The catalog number for Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL is BNC472174-100.

What sizes are available for Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL?

Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL in stock?

Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL?

Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL?

The safety data sheet for Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b9061270361e10c4e7/msds/bnc472174-100.pdf.

What is Cytokeratin 8 (KRT8) (KRT8/2174R), CF647 conjugate, 0.1mg/mL used for?

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18) . CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

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