CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL — image 1 of 2

Product details

CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL

Catalog number BNC472867-100

Price for BNC472867-100

Size / count 1x 100 µL

About this product

This antibody reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI) -anchored cell surface protein (Workshop VI; Code N-L036) . CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) . This MAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC472867-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: 20kDa homologous restriction factor (HRF20) ; Complement regulatory protein; Human leukocyte antigen MIC11; MAC-inhibitory protein (MACIP) ; Membrane attack complex inhibition factor (MACIF) ; Membrane inhibitor of reactive lysis; MIRL; MSK21; Protectin; T cell activating protein
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CD59
Gene ID: 966
NCBI Gene ID: 278573; 709466; 710641
UniProt: P13987
Swiss Prot: P13987
Host: Rabbit
Species Reactivity: Human
Reactivity: CD59
Immunogen: Recombinant full-length human CD59 protein
Target Antigen: CD59
Clonality: Recombinant Monoclonal
Clone: MACIF/2867R
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Field of Research: Hematology, Immunology
Positive Control: Daudi, CEM, K562, HPB.ALL, Jurkat, Raji, and human lymphocytes. Human lymph node and tonsil.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 20 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Species: Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL?

The catalog number for CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL is BNC472867-100.

What sizes are available for CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL?

CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL in stock?

CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL?

CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL?

The safety data sheet for CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0296061270361e100032/msds/bnc472867-100.pdf.

What is CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF647 conjugate, 0.1mg/mL used for?

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.

Is this antibody conjugated?

Conjugation status, such as unconjugated, HRP, FITC, or biotin, is specified in the product name and confirmed on the datasheet.

What is the sensitivity of this ELISA kit?

Assay sensitivity, including the minimum detectable dose, is listed on the datasheet. Kits that are assembled on order typically ship within 2-4 weeks.