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Product details
Catalog number BNC472468-100
Price for BNC472468-100
Size / count 1x 100 µL
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8 T-cells, natural killer cells and some CD4 T-cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF647 conjugate, 0.1mg/mL is BNC472468-100.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2468), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02ac061270361e108058/msds/bnc472468-100.pdf.
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tub
Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.
A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.
Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.
