Presenilin 2/AD5 Recombinant Rabbit Monoclonal Antibody [PSH05-18]

About this product

Presenilin-2 is a protein that (in humans) is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Specifications

Catalog number

HA722243

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AD3L antibody AD3LP antibody AD4 antibody AD5 antibody Alzheimer disease 4 antibody CMD1V antibody E5-1 antibody OTTHUMP00000035671 antibody OTTHUMP00000035672 antibody OTTHUMP00000228286 antibody OTTHUMP00000228288 antibody Presenilin 2 (Alzheimer disease 4) antibody Presenilin 2 antibody Presenilin-2 CTF subunit antibody PS-2 antibody PS2 antibody Psen2 antibody PSN2_HUMAN antibody PSNL2 antibody STM-2 antibody STM2 antibody

Abbreviation

PSEN2, AD4, PS2, PSNL2, STM2

Swiss Prot

P49810 Human, Q61144 Mouse, O88777 Rat

Cellular Locus

Endoplasmic reticulum membrane, Golgi apparatus membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Presenilin 2/AD5 aa 300-400.

Isotype

IgG

Clone

PSH05-18

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP

Positive Control

HeLa cell lysate, HepG2 cell lysate, A549 cell lysate, 293T cell lysate, SH-SY5Y cell lysate, RAW264.7 cell lysate, Neuro-2a cell lysate, C2C12 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, C6 cell lysate, human brain tissue lysate, mouse brain tissue lysate, rat liver tissue lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 50 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes